| (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-γ]isoquinolin-5-yl]-3H-2-benzofuran-1-one; narcotine; noscapine | |
| Links: | 📏 NIST, 📖 PubMed, 📖Houben-Weyl, 2. Band (Narcotin); p. 683, |
| MeSH: | Central Nervous System Agents |
| CAS RN: | [128-62-1] |
| Formula: | C22H23NO7; 413.43 g/mol |
| InChiKey: | AKNNEGZIBPJZJG-MSOLQXFVSA-N |
| SMILES: | COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 |
| Pharmaceutical use: | antitussive; antitussive, myorelaxant |
| Toxicology (LD50): | 41.0 mg/Kg (cat, iv); 71.0 mg/Kg(cat, iv); 2 000 mg/Kg(cat, or); 1 750 mg/Kg(cat, sc); 2 000 mg/Kg(frog, sc); 750 mg/Kg(rat, ip); 800 mg/Kg(rat, ip); 825 mg/Kg(rat, ip) |
| Melting point: | 176 °C |
| 1g dissolves in: 1.88g 2-propanone; 4.00g aniline; 15.38g trichloroethene; 43.48g pyridine; 58.82g piperidine; 96.15g tetrachloromethane; 250.00g diethylamine; 22,471.91g water | |